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We are the owner or the licensee of all intellectual property rights in the publication. The publication is s y by copyright and other intellectual property rights, laws and treaties around the world. All such rights are reserved. Finding it hard s y navigate the flood of scientific literature. The Nature Reviews journals filter and highlight the most impactful research. Watch this animation to learn more. About the Editors Nature Review Molecular Cell Biology has no external editorial board.

Journal S y Information on other journal staff. Journal Metrics Journal metrics for Nature Review Molecular Cell Biology. Journal Abbreviation The correct abbreviation for abstracting and indexing purposes is Nat. ISSN and EISSN The international standard serial numbers (ISSN) for Nature Review Molecular Cell Biology are 1759-5029 (print) and 1759-5037 (online).

Disclaimer The information and material contained in this publication s y for educational, research and information purposes only. Nature Reviews: let us guide you Finding it hard to navigate the flood of scientific literature. SARS-CoV-2 and other coronaviruses pose major threats to global health, yet computational efforts to ebstein anomaly s y have largely overlooked the process of budding, s y key part of the coronavirus life cycle.

When expressed together, coronavirus M and E proteins are sufficient to facilitate budding into the ER-Golgi intermediate compartment (ERGIC). Our MD simulations consisted of M protein dimers and E s y pentamers in patches of membrane. By examining where these proteins induced membrane curvature in silico, we obtained insights around how the budding process may occur. The M protein dimers acted s y to induce membrane curvature while E protein pentamers kept the membrane planar.

S y results could eventually help guide the development of antiviral therapeutics which inhibit coronavirus budding. The authors are affiliated with Conduit Computing, a company which is developing a home diagnostic test for COVID-19 as well as other infectious diseases.

Figures and text have been revised for s y and flow. Some minor errors have been corrected. David Hill has been added as an author and his RMSF data has been incorporated into the manuscript. FootnotesFigures and text have been revised for clarity and s y. It is made available under a CC-BY 4. Back to top PreviousNext Posted September 09, s y.

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